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Paid (1)

Free (15)

Data Analysis Software

MASH Suite

  • Pay For Dissertation Masters Degree

    Ying Ge’s group developed MASH Suite, a user-friendly and versatile software interface for processing high-resolution mass spectrometry data. MASH Suite contains a wide range of features that allow users to easily navigate through data analysis, visualize complex high-resolution mass spectrometry data and manually validate automatically processed results. See paper here.

MS-Align+

  • MS-Align+ is a software tool for top-down protein identification based on spectral alignment that enables searches for unexpected post-translational modifications. MS-Align+ is fast in identifying unexpected post-translational modifications. In addition, MS-Align+ reports statistical significance of top-down protein identifications.

MS-Deconv

  • MS-Deconv is a software tool for top down spectral deconvolution. MS-Deconv uses a combinatorial algorithm. The algorithm first generates a large set of candidate isotopomer envelopes for a spectrum, then represents the spectrum as a graph, and finally selects its highest scoring subset of envelopes as a heaviest path in the graph. In contrast with other approaches, the algorithm scores sets of envelopes rather than individual envelopes.

MSPathFinder

  • Similar to database search engines for bottom-up, it takes a fasta file, a spectrum file, and a list of modifications as an input and reports proteoform spectrum matches (PrSMs) and their scores.

ProSight Lite

ProSight PTM 2

ProSightPC 3.0

Proteoform Characterization Tool

1.0 BETA

  • From our Consortium Paper in New School Creative Writing Mfa Proteomics.

    "The issue of proteoform and PTM scoring arose during workshops and consortium meetings and was identified as a key ambiguity in the field that needs to be addressed."

    "An initial tool was developed for scoring proteoforms of multiply-modified proteins. The input is: (i) an intact mass, (ii) a fragment ion dataset, (iii) a protein sequence, and (iv) the specific kinds of PTMs to be considered. The output is given as a [Phrap] score, where the higher scores are better. Initial use of the tool (available on the website of the Consortium for Top Down Proteomics) is in progress. This software is ongoing in its development and represents our initial attempt to address the pressing issue of formalizing confidence in proteoform characterization."

Protter

  • The ability to integrate and visualize experimental proteomic evidence in the context of rich protein feature annotations represents an unmet need of the proteomics community. Protter is a web-based tool that supports interactive protein data analysis and hypothesis generation by visualizing both annotated sequence features and experimental proteomic data in the context of protein topology. Protter supports numerous proteomic file formats and automatically integrates a variety of reference protein annotation sources, which can be readily extended via modular plug-ins. A built-in export function produces publication-quality customized proteoform illustrations, also for large datasets. Protter is of specific utility for the integrated visual analysis of membrane proteins and peptide selection for targeted proteomics.

TopFIND

TopPIC

  • TopPIC (TOP-Down Mass Spectrometry Based Proteoform Identification and Characterization) is a software tool for identification and characterization of proteoforms at the whole proteome level by top-down tandem mass spectra using database search. It efficiently identifies proteoforms with unexpected mutations and post-translational modifications and accurately estimates statistical significance of identifications. It uses several techniques, such indexes, spectral alignment, and a generation function method, to increase its speed, sensitivity, and accuracy.

YADA

  • Description: YADA can deisotope and decharge high-resolution mass spectra from large peptide molecules, link the precursor monoisotopic peak information to the corresponding tandem mass spectrum, and account for different co-fragmenting ion species (multiplexed spectra). YADA also enables a pipeline consisting of ProLuCID and DTASelect for analyzing large-scale middle-down proteomics data.